NEXT GENERATION FILTRATION

VIBRO® MEMBRANE FILTRATION (VMF)

Vibro® Membrane Filtration (VMF) is a patented, groundbreaking micro- and ultrafiltration technology designed to revolutionize pharmaceutical filtration. Our vibration-based, targeted anti-fouling mechanism enables a uniform, controllable transmembrane pressure, gentle product handling and exceptional performance in an extremely compact, scalable system.

boosts process economy

By combining uniform TMP with vibration‑driven anti‑fouling, VMF enables optimal membrane utilization and stable filtration performance. This results in higher yield and recovery with a substantially smaller footprint and improved process economy.

Protects product quality

VMF uses localized vibrations to create targeted turbulence at the membrane surface only. This lowers overall system shear, protects sensitive cells and biomolecules and enables continuous processing.

scalable

Thanks to its modular build, VMF allows for a seamless, reliable scale-up from process development to full industrial production, supporting efficient tech transfer, reducing risk and accelerating scale-up.

“The Vibro® technology minimizes cake formation in the filtration process, so we are able to get very large quantities through with a high quality. At the same time, there is extremely low energy consumption.”

Nicolas O. Krogh, CEO at Mipsalus

THE FUTURE OF FILTRATION is Vibro®

What if membrane filtration could deliver higher transmission, gentler processing, and dramatically reduced fouling—all in a simple, energy‑efficient design? Vibro® Membrane Filtration (VMF) makes it possible through an innovative vibration-based anti-fouling mechanism that redefines what’s possible in bioprocessing.

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How it works

”The Vibro-I filter is a robust solution, simple to use with no technical issues and with good flux. Power consumption under all operations (microfiltration / ultrafiltration) are much lower than in any known filter technology.”

Science Manager at Novozymes

Frequently asked questions

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“…VMF has reduced fouling and concentration polarization, leading to increased filtration performance, without any negative effects on the biological products.”

Andrew Zydney, Chair and Professor of Chemical Engineering, Penn State University

big claims backed by real data

Our Vibro® Membrane Filtration (VMF) technology is more than innovative—it’s independently validated across the toughest bioprocessing challenges.
In peer-reviewed studies led by Professor Andrew Zydney and the Penn State team, VMF has demonstrated:

  • Up to 20× concentration in a single pass for proteins and mAbs, with robust, long-term operation and minimal fouling.
  • Superior mRNA concentration, achieving high flux, high conversion, and preserving product integrity—even in continuous, 24-hour runs.
  • Consistent, gentle processing that protects sensitive biomolecules and streamlines downstream processing, outperforming conventional TFF in both yield and process economy.

Backed by real data, VMF delivers higher yields, reduced costs, and scalable performance—proven from the lab bench to full-scale production.

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ISO 9001:2015 Certified

This certification is a testament to our customer promise and dedication to deliver products that meet the highest standards in quality, reliability, and performance—every time.

INNOVATION made in denmark

Sani Membranes is more than just a technology provider—we’re a committed industry partner continuously rethinking and challenging what’s possible in micro‑ and ultrafiltration. With our disruptive Vibro® technology and a unified team of specialists, we deliver solutions that elevate our customer’s processes and partner closely with them to solve problems others in the industry can’t.

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Our products

Our VMF system is fully scalable and available in sizes from 35 cm2 to 80 m2 membrane area.
Explore our product catalogue:

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