
Single-Pass VMF of mRNA
Single-Pass VMF significantly enhances the performance of in-line concentration and purification of mRNA constructs, with more than triple the sustainable flux rates reported for conventional single-pass TFF.

Single-Pass VMF significantly enhances the performance of in-line concentration and purification of mRNA constructs, with more than triple the sustainable flux rates reported for conventional single-pass TFF.

VMF performs better than conventional TFF for the processing of high‑density E. coli cultures and lysates, making it a robust, high-performance solution for demanding midstream applications.

Precipitation combined with Single-Pass Vibro® Membrane Filtration (VMF) is an interesting alternative to Protein A chromatography for the continuous purification of precipitated mAbs.

VMF technology delivers a step change in protein ultrafiltration performance. It enables higher productivity, lower operating pressure and improved process robustness in bioprocessing, particularly for the concentration of monoclonal antibodies (mAbs) and other high‑value protein products.

Single-pass VMF outperforms conventional single-pass TFF in the concentration of mAbs, with minimal fouling, high concentration and conversion efficiency and gentle, stable operation.

In the following example, the Vibro® Technology is applied in an extracellular API/protein process where the fermentation broth is processed directly, and a…

In this example, a fermentation broth containing cells such as E. coli bacteria is being harvested and concentrated directly from the harvest…

In the following example, the Vibro® Technology is applied to a Greek Yoghurt process where the cultured skim milk is concentrated to Greek…

Vibro® Membrane Filtration (VMF) enables the continuous and highly efficient harvest and concentration of algae. Within just a three steps, concentrations of 200…