Single-Pass mRNA concentration using Vibro® Membrane Filtration (VMF)
Transforming pharmaceutical filtration
Vibro® technology has a unique vibration-based antifouling mechanism that ensures uniform, controllable TMP, low shear, and exceptional performance.
Enables efficient continuous operation
With a stable, low-shear anti-fouling mechanism, the Vibro® Single-Pass VMF is superior to conventional Single-Pass TFF. Sustainable performance was maintained over 24 hours of continuous operation, showcasing its suitability for continuous biomanufacturing.
mRNA constructs preserved
In a 24-hour continuous processing study, Vibro® VMF maintained mRNA integrity, as confirmed by SEC and electrophoresis analyses.
Three-fold performance gain
In test with two different mRNA constructs, Vibro® Single-Pass VMF achieved:
• >3X filtrate flux compared to conventional technologies
• ~95% conversion rate
• up to 20X concentration factor
A breakthrough in continuous mRNA processing – combining efficiency, scalability and product preservation.
Read the complete study
Vibration-assisted ultrafiltration dramatically improves mRNA purification.
A. Behboudi, A. Javidanbardan , Z. Wang , L. Zhou, A.L. Zydney
Separation and Purification Technology 363 (2025) 132179.