VMF clarification of E. coli & lysates
VMF outperforms conventional TFF in terms of process time, suspended solid
loading and target protein recovery in demanding midstream applications.
Helena Maier
Mass transfer characteristics of VMF Protein UF
VMF technology delivers a step change in protein ultrafiltration performance. It enables higher productivity, lower operating pressure and improved process robustness in bioprocessing, particularly for the concentration of monoclonal antibodies (mAbs) and other high‑value protein products.
Single-Pass VMF mAbs
Single-Pass VMF outperforms conventional SPTFF with minimal fouling, high concentration efficiency, and gentle, stable operation. It enables true Single-Pass concentration in a single step — a breakthrough in continuous bioprocessing.
Filtration of Biologics in Continuous/Perfusion processes
In this example, the Vibro® Membrane Filtration (VMF) technology is used as perfusion device to retain cells in the bioreactor and to harvest API in the permeate from VMF1. Description: Use of VMF to treat bleed stream by harvesting API…
Harvest of Mammalian Cell Cultivations
In the following example, the Vibro® Membrane Filtration (VMF) technology is used for the critical solid/liquid separation following cultivation of mammalian cells. Description: Vibro® technology has proven to be an effective means of cell removal from cultivation broth, both in microbial and…
API/Protein Concentration & Recovery
In the following example, the Vibro® Technology is applied in an extracellular API/protein process where the fermentation broth is processed directly, and a concentrated API/protein is achieved. Description: The fermentation broth is processed in a Vibro-I microfiltration unit where the cells are separated…
Concentration of E.Coli
In this example, the fermentation broth containing E. coli bacteria has been harvested and concentrated directly from the harvest tank using VMF technology. Description: VMF is characterized by having very low flow resistance and being capable of uniform TMP, while…
Single step clarification of API
In this example, VMF is used for an extracellular clarification process, where the fermentation broth is processed directly to a clear, and a cleaned API/protein is achieved. Description: Due to the unique VMF technology, this setup can also be used…
Concentration of Skim Milk to Greek Yoghurt
In the following example, the Vibro® Technology is applied to a Greek Yoghurt process where the cultured skim milk is concentrated to Greek Yoghurt. Description: The cultured milk is processed in a Vibro-I unit with 3 steps. The first step is…
Algae Harvest
In the following example, the Vibro® Membrane Filtration (VMF) technology is used for algae harvest and concentration. Description: Algae culture from a pond or a photo bioreactor is processed continuously or as batch with plug flow through a Vibro-I preconcentration system…